
The event
Periodontitis, the most common inflammatory disease of man, is an infectious/inflammatory disease associated with dysbiosis of the commensal oral microbiome. Gingivitis affects >90% of people, and periodontitis, with irreversible tissue destruction, affects more than 45% of the population worldwide. New research has shown that the therapeutic target for the treatment of periodontal diseases is inflammation via host modulation. We can only hope to slow it down by antimicrobial approaches. To definitively treat the disease, we must control inflammation directly. Our body produces mediators of resolution of inflammation that have provided new approaches for the management of periodontitis. Specialized proresolving lipid mediators (SPMs) can be used for the prevention and treatment of periodontitis by preventing and reversing inflammation. These compounds are safe and efficacy data in humans reveals that a specific SPM reduces gingivitis and established periodontitis in humans.