CopiOs® Xenograft Particulates

CopiOs Cancellous
Bovine Particulate Xenograft

Key Benefit:
CopiOs Xenograft does not undergo thermal treatment during processing, for this reason CopiOs Xenograft will be remodeled into newly formed vital bone after a period of time. (ref. 1, 2)

Clinical Advantages
Retains osteoconductive properties due to the preservation of the original bovine bone matrix collagen and mineral composition, trabecular pattern and original porosity (ref. 3)
• Biocompatible and well-tolerated as shown in animal and human studies (ref. 2,4,5,6)
• Ability to remodel into vital bone (ref. 2,6,7)
• Proven performance in large and small bone defects (ref. 2,5,8)

Shown Clinically Successful In:
• Regeneration of periodontal bone defects (ref. 9,10)
• Grafting procedures around immediate placed implants (ref. 8,9,11)
• Alveolar ridge augmentation (ref. 5,9,12)

1. Data on File with RTI Surgical Inc. 2. Tudor C. et al. Oral Surg Oral Med O (2008) 105:430-436. 3. Tadic D. et al. Biomaterials (2004) 25:987-94. 4. Trentz O.A. et al. Biomaterials (2003) 24:3417-26. 5. Perret F. et al. Int J Periodontics Restorative Dent (2018) 39:97-105. 6. Thorwarth M. et al. Br J Oral Maxillofac Surg (2007) 45:41-7. 7. Günther K.P. et al. Osteologie (1996) 5:4-12. 8. Peron C. et al. Int J Periodontics Restorative Dent (2020) 40:417-424. 9. CopiOs Xenograft Particulates IFU latest revision. 10. Stavropoulos A. et al. J Periodontol (2011) 82:462-470. 11. Longoni S. et al. J Osseointegration (2016) 8:8-13. 12. Marei H.F. et al. Egypt Dent J (2017) 63:2281-2288.